This protocol induces a highly polarized type 2 pathology, with increased frequencies of these relatively homogenous Th2 cells in their lungs and airways that correlate strongly with many features of type 2 asthma including eosinophilia, T2 cytokine production, airway hyperresponsiveness, and allergen-specific IgE. The gene discussed is IGHE; the disease is airway hyperresponsiveness.