High-resolution single-cell RNA sequencing (scRNA-seq) of house dust mite (HDM)–specific CD4 T cells from human peripheral blood, assessed after restimulation with HDM ex vivo, confirms the enhanced expression of survival and functional factors in Th2 cells from allergic asthmatics compared not only with healthy controls but also to HDM-allergic individuals without asthma (Seumois et al., 2020). This evidence concerns the gene CD4 and asthma.