However, analysis of different endotypes generally focuses on clinical symptoms associated with type 2 immunity, such as eosinophilia, serum IgE, and exhaled nitric oxide, or the general levels of type 2 cytokines, but analyses rarely reach the level of granularity such that type 2 cell populations are identified (Fig. 1). This evidence concerns the gene IGHE and Increased total eosinophil count.