Based on the PPI network analysis using STRING and CytoHubba, we further identified 10 important targets in the therapeutic effect of costunolide in AIH, namely MAPK1, SRC, GRB2, EGFR, LCK, ESR1, JAK2, IGF1, HSP90AA1, and IGF1R, ranked by MCC. This evidence concerns the gene MAPK1 and autoimmune hepatitis.