Using plug-in CytoHubba, we found top 10 genes that might play critical roles in the therapeutic effect of costunolide in AIH, namely MAPK1, SRC, GRB2, EGFR, LCK, ESR1, JAK2, IGF1, HSP90AA1, and IGF1R, ranked by Maximal Clique Centrality (MCC) (Figure 5b). This evidence concerns the gene ESR1 and autoimmune hepatitis.