Based on the PPI network analysis using STRING and CytoHubba, we further identified 10 important targets in the therapeutic effect of costunolide in AIH, namely MAPK1, SRC, GRB2, EGFR, LCK, ESR1, JAK2, IGF1, HSP90AA1, and IGF1R, ranked by MCC. Here, HSP90AA1 is linked to autoimmune hepatitis.