CTBP2 and Familial prostate cancer: Second, CtBP2 is overexpressed in cancer, including prostate cancer, ovarian cancer, liver cancer, breast cancer, and esophageal squamous cell carcinoma (Cerami et al, 2012; Gao et al, 2013; Takayama et al, 2014; Zhang et al, 2015; Zheng et al, 2015).