DMXL2 and hearing loss disorder: Family studies have led to the identification of many variants involved in adult-onset Mendelian hearing loss (for example, MIR96 (Mencia et al. 2009), DMXL2 (Chen et al. 2017), reviewed in (Ahmadmehrabi et al. 2021)), but these tend to be very rare or even private variants, and are unlikely to explain all of the hearing loss seen in humans.