This information could contribute to a better understanding of the role of butyric acid in regulating AD pathogenesis, including that lysine (K) 15 of GSK3β is a critical acetylation site in regulating phosphorylation of GSK3β at serine 9 following treatment of butyric acid, which then leads to alterations in Tau phosphorylation. The gene discussed is MAPT; the disease is Alzheimer disease.