OPA1 and Behcet disease: On the other hand, subjects (BD and Non-psychiatry controls) with higher MHI showed higher levels of Opa-1 [a protein involved in the maintenance of the respiratory chain and membrane potential, cristae organization, and control of apoptosis] and LC3 [a key component of autophagy/mitophagy], suggesting that mitochondrial fusion may account for a higher bioenergetic capacity.