CXCR4 and diffuse large B-cell lymphoma: This confirms that at least the corticosteroid component of stabilizing chemotherapy regimens in DLBCL patients [8, 9] prior to CXCR4-targeted RLT with [177Lu]Lu-PentixaTher does not lead to downregulation of the molecular target CXCR4 and may even have a contrary, beneficiary effect.