Of note, analysis of previously acquired aortic intima-media proteomic expression [13] showed that LAMC1/TAGLN protein expression was inversely associated with ascending aortic dimensions in BAV patients (P = 0.004, Pearson correlation =  − 0.818) (Fig. 4c), suggestive of a BM reorganization during aortic dilatation. This evidence concerns the gene TAGLN and Vascular dilatation.