In brief, eight SNPs were identified in direct relationships: IL1B, rs1143627 and IL1B, rs16944; IL2, rs2069762 and sex (greater frequency of homozygous variant genotype in males); IL10, rs1800871 and IL10, rs1800896; IL10, rs1800871 and asthma; IL6R, rs8192284 and constipation; TLR2, rs3804100 and osteoarthritis; TLR4, rs4986790 and TLR4, rs4986791; MD2 (LY96), rs11466004 and IL10, rs1800871; and CASP5, rs554344 and CASP1 (ICE), rs580253. This evidence concerns the gene CASP5 and osteoarthritis.