IL6R and cancer: The direct links between adverse effects and predictors, some of which were novel, were minimal and included: treatment hospital and cardiotoxicity/fatigue; IL6R rs8192284 and constipation; sex and diarrhea; cancer type and neuropathy; fluoropyrimidine-based chemotherapy regimen type and neuropathy/hand–foot syndrome; alcohol use and generalized pain; and various links between the different adverse effects.