CRP and Cowden disease: Although FC has high accuracy in assessing mucosal inflammation in colonic CD, a systematic review has shown that FC has more modest sensitivity (36%-77%) in detecting active inflammation in SB CD.29 C-reactive protein was reported to be more useful to discriminate inactive/mild from moderate–severe activity in SB CD.30 These findings further confirm that there is a partial disconnect between clinical symptoms, biomarkers, and mucosal inflammation in CD patients with SB inflammation, even in patients with moderate to severe luminal endoscopic activity.