For example, fibulin-1 and fibulin-5 are known to be associated with tumorigenesis and metastasis in HCC.6,7 Located between the elastin core and the microfibrils, FBLN2 acts as a calcium-binding glycoprotein binding and interacting with a variety of ECM components.8,9 Previous studies highlighted its involvement in the elastogenesis of blood vessels, which is most seen in diseases like atherosclerosis, acute aortic dissection, and hypertension that are closely related to ECM reorganized and desmoplasia.10,11. The gene discussed is FBLN2; the disease is hepatocellular carcinoma.