For example, high FBLN2 is related to adverse pathologic variables including tumor invasion and metastasis in urothelial carcinoma.8 Fibulin-2 is also a driver of migration and invasion of lung adenocarcinoma cells.9 However, FBLN2 impairs the invasion and migration in breast cancer.16 Considering the pathological progression from cirrhosis to HCC, the role of FBLN2 in HCC aroused our interest. The gene discussed is FBLN2; the disease is breast carcinoma.