The etiology of EGE is still unclear, but it is currently thought to be an allergic and immune-inflammatory disease.18 Several studies have revealed that TRAF6 is related to various allergic and immune-related diseases, such as asthma, systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), IBD,19-21 and so on. Here, TRAF6 is linked to rheumatoid arthritis.