CAD is activated by ribosomal protein S6 kinase beta-1 (S6K1), a downstream effector of the AKT-mammalian target of rapamycin (mTOR) signaling pathway, which regulates a wide range of cellular processes, including survival, proliferation, growth, metabolism, angiogenesis, and cancer metastasis (27, –, 29). Here, RPS6KB1 is linked to cancer.