We hypothesize that ADAR1 contributes to an immunosuppressive tumor microenvironment in primary LUAD foci by increasing pro‐cancer M2 macrophages, whereas after metastasis to lymph nodes, ADAR1 contributes to an immunosuppressive microenvironment favorable to tumor cell growth mainly by suppressing anti‐cancer M1 macrophages. This evidence concerns the gene ADAR and cancer.