In the present research, paclitaxel decreased the expression of stathmin 1, and propofol at high concentrations enhanced the effect of paclitaxel on stathmin 1 expression in cervical cancer cells, indicating that propofol and paclitaxel synergistically suppress the malignancy of cancer cells by downregulating the expression of stathmin 1. This evidence concerns the gene STMN1 and cervical cancer.