Pim kinase is involved in the regulation of the MM cell cycle by acting on p21Cip1/Waf1(CDKN1A), p27Kip1(CDKN1B), and CDC25A/C via their phosphorylation pathways,37 but there is no consensus on whether pim kinase accelerates the cell cycle or causes it arresting. This evidence concerns the gene CDKN1B and Miyoshi myopathy.