APOE and Alzheimer disease: Two Astro cell‐specific loops (loop1, loop3) in the locus link the APOE promoter to three active enhancers (EH1, EH2, EH3) identified by SnapHiC.[62] It is known that Astro cells are associated with AD.[63, 64, 65] EH1, EH2, and EH3 are also located around the Astro‐specific subTLD boundary, EH1 and EH2 carry AD‐associated GWAS SNPs (rs112481437, rs138137383) (Figure 6b–d).