Npr1 null animals show hypertension, ventricular fibrosis and cardiac hypertrophy (Lopez et al., 1995; Oliver et al., 1997), while Npr2 mutant animals are affected by dwarfism, due to impaired endochondral ossification, and female infertility (Tamura et al., 2004). The gene discussed is NPR2; the disease is Severe short stature.