Non-sex specific pathways that were enriched in protected WT females included vasculogenesis and response to lipids, providing molecular hints to genes that are associated with protection from obesity and inflammation, e.g. TGFβ (Tgfb1, Tgfbr2, Tgfbr3), Th2 cytokine signaling (Il4, Il4ra, Il13), and matrix remodeling (connexins, metallopeptidases). The gene discussed is TGFBR3; the disease is obesity disorder.