GPT and Pruritus: Study end points that are similar for the TXR140 monotherapy and TXR140 + CVC combination group (eg, lipids, ALT, and GGT) may be more dependent on Cmin, whereas for the stronger effects seen in the TXR140 monotherapy group (eg, pruritus and weight loss), the higher total exposure (AUC and Cmax) may contribute.