A similar decrease in ALT from baseline with TXR was observed in the FLIGHT-FXR study.14 With a number of studies suggesting that a ≥30% relative reduction in HFF measured by MRI-PDFF may be associated with histologic response in NASH trials,30,31 it is interesting to note that in our study, this level of reduction in HFF was observed in several of the FXR-containing arms without notable histologic response. This evidence concerns the gene GPT and metabolic dysfunction-associated steatohepatitis.