Among the patients withclinically actionable LP/P variants, 47 (47/133, 35.3%) were associated with LS,MLH1, MSH2, MSH6, and PMS2 (Group 1).Among this group, 3 patients had 2 clinically actionable LP/P variantsidentified, MLH1/APC, MLH1/PMS2, andPMS2/HOXB13. The overall yield of LS was 3.48% (47/1,350)among patients who completed testing. This evidence concerns the gene MSH2 and Leigh syndrome.