Theremaining patients (70/133, 52.6%) were found to have LP/P variants in genes nottypically associated with hereditary colorectal cancer and included thefollowing: AIP, ATM, BARD1, BRCA1, BRCA2, BRIP1, CDKN2A, CHEK2, FH,FLCN, HOXB13, MITF, NBN, NF1, PALB2, PTEN, RAD50, RAD51 C, RAD51D, SDHD,TP53, and TSC2 (Group 3). The gene discussed is CHEK2; the disease is familial colorectal cancer.