As a consequence, the tumor immune microenvironment was remodeled (Fig. 10 and Fig. S9), as evidenced by the reduced immunosuppressive MDSC (Fig. 10G), the amplifying NK cells (Fig. 10H) and CD8+ T cells (Fig. 10I), and the increasingly released cytotoxic substances granzyme B and INF-γ (Fig. 10J and K). This evidence concerns the gene CD8A and neoplasm.