The tumor immune microenvironment (TME) was remodeled and the activated anticancer immunity was characterized by the decreased immunosuppressive MDSC amount (Fig. S6C and Fig. S7), and the increased NK cells (Fig. S6D and S6E), CD8+ T cells (Fig. S6F), cytotoxic substances granzyme B and INFγ (Fig. S6G and S6H). Here, GZMB is linked to neoplasm.