In order to complete the construction of the potential ceRNA network in CRC progression, the key prognostic genes (APOD, DNASE1L3, GRB7) as well as the key prognostic miRNA (hsa-miR-2355-3p, hsa-miR-1226-3p), lncRNA (ELFN1-AS1) were identified by taking the intersection of eight prognostic genes and DEGs, targeted miRNA and DEmiRNA, targeted lncRNA and DElncRNA, respectively. This evidence concerns the gene GRB7 and colorectal carcinoma.