However, imbalance between inflammation and restoration responses contributes to the worsening of lung injury from pneumonitis to pulmonary fibrosis, and their potential biomarkers including inflammation-related factors (IL-1β, IL-6, IL-8, IL-10 and CRP) and fibrosis-related factors (TGF-β, ET-1, KL-6, and PAI-1) have been reviewed previously [27]. The gene discussed is SERPINE1; the disease is pneumonitis.