IGF1 and acromegaly: However, Vialon et al. [9] recently reported a prevalence of up to 50%, with a 66.7% frequency of GDM when IGF-1 secretion was controlled before pregnancy vs. 37.5% in the pregestational uncontrolled group, which suggested besides classical risk factors of GDM, such as age and BMI, lack of GH/IGF-I hypersecretion control may also aggravate the risk of GDM in acromegaly.