IDH1 and glioblastoma: In order to facilitate mouse-to-human translation, we have recently developed a highly stable preclinical mouse GBM model, named as G422 triple-negative GBM (G422TN-GBM) based on its genetic combinations of IDH1/2WT chromosome1/19Intact TERT-promoterWT with ATRXMutant Trp53Mutant [13].