In our intracranial G422TN-GBM model, most G422TN-cells on day 9 p.i. possessed a much higher ROS level than their neighboring normal cells but cell death was scarce (Figs. 4 and 5), suggesting that G422TN-cells had achieved a higher balanced level of ROS/antioxidants along rapid tumor growth (large amounts of Ki-67-positive G422TN-cells). Here, MKI67 is linked to neoplasm.