Our study showed that tumor location, lymph-node metastasis, pTNM stage,and high-AFP level were associated with poor prognosis of HAS, whereas multivariable analysis confirmed that surgical resection could effectively prolong survival and reduce primary tumor recurrence or progression.We speculate that early diagnosis of HAS and surgical resection may be critical to improve prognosis. The gene discussed is AFP; the disease is metastatic malignant neoplasm in the lymph nodes.