NSUN2 and neoplasm: As expected, overexpression of NSUN2-WT but not NSUN2-DM led to a rapid tumor formation and increased tumor burden compared to Mock group; meanwhile, overexpression of NSUN2-WT, but not NSUN2-DM, significantly decreased sensitivity to gefitinib treatment compared to the control group; moreover, tumors of NSUN2-WT overexpression were more prone to recurrence after discontinuation of gefitinib treatment, whereas NSUN2-DM had no such effect (Fig. 2d, e).