Finally, analysis of TCGA database revealed that the combined high expression of NSUN2, YBX1 and QSOX1 predicted the poorest overall survival in lung adenocarcinoma (LUAD) (Fig. 7i), breast cancer (BRCA) and hepatocellular carcinoma (HCC) (Figure S9g). The gene discussed is NSUN2; the disease is hepatocellular carcinoma.