As cytokines play a key role in the pathogenesis of CML [24], we next assessed their expression levels in BM and spleen from ScltTA/TRE-BCR::ABL1 mice either crossed with Cpa3Cre/+ or Gab2−/− mice (Fig. 4; Supplementary Fig. S4). This evidence concerns the gene ABL1 and chronic myelogenous leukemia, BCR-ABL1 positive.