VIM and neoplasm: Data from the KPV−/− GEMM show that vimentin is required for metastasis and tumor progression (Figs. 1 and 6), as KPV−/− mice had decreased lung tumor burden (Fig. 1C, Supplementary Fig. S1H), lower-grade tumors (Supplementary Fig. S1K), and no metastasis from primary tumors in the flank to the lung (Fig. 6A–C).