These data expand on recent reports associating IDH1R132H with reduced CD8 T cell gene expression in TCGA gliomas [17], which implicated 2HG-mediated inhibition of CXCL10 production in lower T cell recruitment and metabolic reprogramming in CD8 T cells leading to anti-glioma immunosuppression [24, 25]. Here, CXCL10 is linked to central nervous system cancer.