TNF and systemic lupus erythematosus: Additionally, GSEA also revealed an association with immunologic signature terms, including “GSE10325 CD4 T-cell vs lupus CD4 T-cell up”, “GSE19198 1 h vs 24 h IL21 treated T-cell up”, “GSE15930 naïve vs 24 h in vitro stim CD8 T-cell down”, “GSE18893 tconv vs treg 24 h TNF stim up”, etc. (Fig. 4E,F).