Among these hub genes, 14 genes including CCL26, CD1A, CLCNKB, CXCL1, CXCL3, CXCL5, IL2RG, IL18, KCND2, KCNG1, MMP1, MMP7, STMN2 and TUBB3 were significantly associated with inferior OS in AML patients (Supplementary Fig. S4). Here, CXCL1 is linked to acute myeloid leukemia.