Among these hub genes, 14 genes including CCL26, CD1A, CLCNKB, CXCL1, CXCL3, CXCL5, IL2RG, IL18, KCND2, KCNG1, MMP1, MMP7, STMN2 and TUBB3 were significantly associated with inferior OS in AML patients (Supplementary Fig. S4). The gene discussed is CD1A; the disease is acute myeloid leukemia.