However, Stevens and Meech et al. found increased expression of BARX2 in breast cancer tissues31, with upregulation of the expression of MMP9 and inhibitor of metalloproteinases 4 (TIMP4), which ultimately promoted invasion and migration of breast cancer cells, contradicting our current results, probably due to differences in the tumour tissue subtypes studied. The gene discussed is TIMP4; the disease is breast carcinoma.