By comparing candidate biomarkers using ANOVA (excluding APOE allele-specific peptides), we found 41 differentially expressed peptides (36 proteins) in AsymAD vs controls (Fig. 6a), 35 differentially expressed peptides (30 proteins) in AD versus controls (Fig. 6b), and 21 differentially expressed peptides (18 proteins) in AD vs AsymAD (Fig. 6c). The gene discussed is APOE; the disease is Alzheimer disease.