To study the impact of cell-type specific loss of P53 on hematopoietic neoplasia, we generated two different models of Trp53 gene deletion—a pan-hematopoietic deletion of Trp53 and a B-cell specific deletion of Trp53—And characterized tumor formation, lineage, and gene expression changes in each of the models. Here, TP53 is linked to neoplasm.