To further query the differences between B-cell lymphoma and normal B-cell subsets, we performed transcriptome profiling of sorted follicular and marginal zone B-cells from floxed P53 and CD19-P53CKO mice at 12 weeks and 24 weeks (n=3 from each group), compared with diffuse lymphoma cells from 5 CD19-P53CKO mice. Here, TP53 is linked to B-cell non-Hodgkin lymphoma.