In the same way, when cancer-related transcriptome was investigated using digital transcriptomics, MUC1 expression was revealed to be dependent on TG2 expression, since TG2KO lowered MUC1 expression and TG2 re-expression restored wild-type levels of MUC1; in particular the truncated TG2 isoform significantly restored MUC1 when transfected back in the TG2KO clones. The gene discussed is MUC1; the disease is cancer.