Here we show that editing of TGM2 gene by CRISPR-Cas9 in two metastatic PCa cell lines (PC3 and DU145) reverses the metastatic PCa cell phenotype, and that selective knock-in of the truncated TG2 isoform leads to specific transcriptomics, uncovering a new link between TGM2_v2 and the oncoprotein Mucin-1 (MUC1) [28] which is mediated by AR downregulation. Here, AR is linked to posterior cortical atrophy.