Androgen-insensitive PCa metastatic cell lines PC3 and DU145 displayed canonical TG2 protein (Fig. 1A-I) capable of calcium-dependent transamidation (Fig. 1A-II), whereas androgen-sensitive PCa cell lines either metastatic cell line LNCaP or non-metastatic PC346-Flu1 and PC346-Flu2 cell lines lacked TG2 protein expression or transamidation activity (Fig. 1A-I, II). Here, TGM2 is linked to posterior cortical atrophy.