TNF and psoriasis: It has also been suggested that psoriatic lesions contain numerous TLR7-expressing plasmacytoid DC infiltrates and that upon binding to its ligand, TLR7 induces DC-regulated immune responses, which promote the release of inflammatory mediators and cytokines (e.g., IL-8, TNF-α) and contribute to the inflammatory response in psoriasis mainly through the MyD88-dependent signaling pathway.