Skin tissue RT-PCR detection determined that the IMQ + PBS groups in all three psoriasis mouse models had significantly increased TNF-α, IL-1, IL-6, IL-12, IFN-α, IFN-β, IFN-γ, G-CSF, GM-CSF, IL-36α, IL-36β, and IL-36γ gene expression compared to the NC groups. The gene discussed is IL36B; the disease is psoriasis.