Tfeb silencing in all melanoma cells reduced the catalytic activity of glutaminase (GLS) without modifying its expression (Supplementary Fig. S5D, Supplementary Fig. S5E and Table 1), but it had no effect on glutamic dehydrogenase (GLU DH) activity (Supplementary Fig. S5D and Table 1). The gene discussed is TFEB; the disease is melanoma.