For example, exosomal miR-124 from ovarian cancer targets sphingosine kinase 1 (SPHK1) and elevates fibroblast activating protein (FAP) and α-smooth muscle actin (α-SMA) to differentiate NFs into CAFs and controls CAF migratory and invasive capabilities, thus promoting tumor progression [71]. This evidence concerns the gene SPHK1 and ovarian carcinoma.