KANSL1L and congenital heart disease: Interestingly, (Lalani 2020) reported that the cardiac phenotype in humans is probably associated to an imbalance of other genes within the deleted interval as congenital heart disease was not found in individuals with single nucleotide variations in KANSL1. Homozygous Kansl1 KO mice are not viable (embryonic lethal (Li et al. 2022)) and therefore homozygous Kansl1l mutant mice were generated as a viable Kansl1l KO model in the GMC.