Among other characteristics, individuals homozygous for RAB3GAP1 present failure to thrive, intellectual disability, corpus callosum hypoplasia, diffuse cortical or subcortical atrophy, congenital cataracts, microcornea and microphthalmia (Morris-Rosendahl et al. 2010). Here, RAB3GAP1 is linked to early-onset non-syndromic cataract.