Acsf3 KO mouse model of a RD of combined malonic and methylmalonic aciduria, presented significant mouse phenotypic traits related to an increased circulating iron (p < 0.001, MP:0008810) and decreased circulating unsaturated transferrin levels (p = 0.021, MP:0011897), suggestive of hemolytic anemia or liver disease. This evidence concerns the gene TF and liver disorder.