Logistic regression analysis showed, that the association between AMD and autoantibody level was still present after including the following parameters as independent variables into the model to adjust for: (yes vs. no), body-mass-index, HbA1c level, level of high-density lipoproteins, of low-density lipoproteins and triglycerides (all continuous) in case of mitogen-activated protein kinase 3 (p=0.04), lysozyme (p=0.013), transferrin (p<0.007) and protein kinase C substrate 80K-H (p=0.019) and insulin (p=0.02) (Table 4). The gene discussed is INS; the disease is age-related macular degeneration.