Logistic regression analysis showed, that the association between AMD and autoantibody level was still present after adjustment for smoking, body-mass-index, HbA1c level, level of high-density lipoproteins, of low-density lipoproteins and triglycerides in case of mitogen-activated protein kinase 3, lysozyme, transferrin and protein kinase C substrate 80K-H , insulin and heat shock 70 kDa protein 1A. The gene discussed is PRKCSH; the disease is age-related macular degeneration.