DNMT3A and acute myeloid leukemia: Clonal hematopoiesis is caused most frequently by somatic mutations in DNMT3A, which are also a common feature of normal karyotype acute myeloid leukemia (AML) (Ley et al. 2010, 2013; Jaiswal et al. 2014; Xie et al. 2014; Genovese et al. 2015).