The G protein α-subunit GNAQ is mutated in 46% of uveal melanomas and 84% of blue nevi samples (van Raamsdonk et al. 2009) and is less frequently (2.4%) altered in cutaneous melanoma, suggesting that DNMT3A loss of function may be more impactful for melanoma development in certain contexts. The gene discussed is DNMT3A; the disease is melanoma.