DNMT3A and overgrowth syndrome: The proband is a male diagnosed with DNMT3A overgrowth syndrome, with a de novo heterozygous insertion in the DNMT3A gene (c.1238dupG) resulting in DNMT3AF414fs*; peripheral blood cells from this patient had been analyzed in a prior report demonstrating a haploinsufficiency phenotype for DNA methylation (Smith et al. 2021).