The expression of MTHFD2 mRNA is reported to be elevated in cardiovascular disease (Hitzel et al, 2018); note that PHGDH mRNA encoding cytosolic phosphoglycerate dehydrogenase (second from the bottom in the heart > erythrocyte category), which participates in MTHFD2-controlled amino acid metabolism, is also reported to be increased in cardiovascular disease (Hitzel et al, 2018). This evidence concerns the gene MTHFD2 and cardiovascular disorder.