Because of its potent glucose-elevating efficacy, glucagon plays a key role in glucose counter-regulation against hypoglycaemia and has been used as an emergency antidote for severe hypoglycaemia (Elrick et al. 1958), a life-threatening medical condition of dangerously low blood glucose that is often caused by iatrogenic use of insulin/insulin secretagogues. The gene discussed is INS; the disease is Hypoglycemia.