Xie et al. [42] have detected evidence of upregulation of the NOTCH signaling cascade, a well-known signaling pathway that has been proven to contribute to the development of some human cancers, and its genetic receptor NOTCH1, as well as its downstream gene HES1, in the carcinogenesis, invasion, and metastasis of SACC, potentially by promoting the epithelial-mesenchymal transition (EMT)-related genes [42]. The gene discussed is HES1; the disease is cancer.