Given the notion that cytosolic localisation, phosphorylation, and insolubility are all characteristic hallmarks of TDP-43-proteinopathies(Arai et al., 2006; Neumann et al., 2006; Winton et al., 2008; Neumann et al., 2009; Wegorzewska et al., 2009; Barmada et al., 2010; Da Cruz et al., 2011; Hasegawa et al., 2011; Halliday et al., 2012; Arnold et al., 2013; Liachko et al., 2014; Sugai et al., 2019), we subsequently investigated whether hTDP-43 worms show any of these molecular features. The gene discussed is TARDBP; the disease is proteostasis deficiencies.