TP53 and cyclic hematopoiesis: In fact, TP53 is among the 5 most frequent genes found to be associated with clonal hematopoiesis (CH).13,14 Approximately 20% of commercial laboratory multigene panel tests reports of pathogenic/likely pathogenic variants in TP53 represent aberrant clonal expansion rather than a true germline finding.15,16 Acquired mutation patterns in hematopoiesis can result in dominance of a subset of hematopoietic stem and progenitor cells.