SMAD3 and endometriosis: Individual candidate target genes identified between multiple endometriosis comorbidities include genes in the 1p36.12 locus, ESR1, GREB1, FSHB, SKAP1, CASC10, MLLT10, ARL14EP, SNX11, CBX1, CDKN2B-AS1, and SMAD3 (Fig. 5).