IGF1 and Parkinson disease: IGF-1 was significantly elevated at both -10 to -5 years (22.87 +/- 5.74, P<0.001) and -5 to 0 years before diagnosis (23.46 +/- 6.14, P<0.001) and 0–5 years after diagnosis in males (24.78 +/- 7.68, P<0.001) compared to non-PD (21.47+/-5.33, Fig 5A).