In patients with SCD, the spleen is the first organ to be affected.12 Splenic damage resulting from SCD reduces IgM levels, which increases the risk of encapsulated bacterial infections.13 Furthermore, children with SCD are predisposed to osteomyelitis as increased hematopoiesis compensates for chronic hemolysis.13 In the case of SCD, functional hyposplenia or asplenia caused by the sickle cells results in a decreased ability to filter phagocytic cells and produce antibodies.14 Morbidity and mortality in SCD are commonly caused by encapsulated bacteria Salmonella spp. Here, CD40LG is linked to Schnyder corneal dystrophy.